The TEM8 cell receptor is commonly found in cells lining the blood vessels of tumors.
The newly revealed structure also points to a potential new tumor treatment using a genetically modified anthrax toxin, said Dr. Liddington. The TEM8 cell receptor is commonly found in cells lining the blood vessels of tumors. Although the structure of receptor TEM8 has not been determined, scientists expect it to be similar to that of the CMG2 receptor. ‘Computer modeling could enable us, a version of the anthrax toxin that only binds to TEM8 and CMG2 not design,’he says. Such a toxin would kill tumor cells while normal cells unharmed.
Reference:. E Santelli et al Crystal structure of a complex between anthrax toxin and its host cell receptor. DOI: 10.1038/nature02763.genetic mutations protein degradation subject Inherited ALS LinkedA new study shows a previously unknown mutation, an inherited form of amyotrophic lateral sclerosis caused.A new study reveals a previously unknown mutation, an inherited form of amyotrophic lateral sclerosis causes. The study, by Cell Press in the 9th December issue of the journal Neuron published implies defects in a cellular pathway with the degradation of unwanted proteins in the underlying pathology of ALS linked and provides new insight into this incurable and fatal neurodegenerative disorder..The names of the women who in the study was changed to safeguard their anonymity.
– A life influenced with pains: women and endometriosis. Annette Huntingdon, Association of Prof. And Jean A Gilmour, Senior Lecturer in, Massey University, Wellington, New Zealand. Journal of Clinical Nursing, Volume 14, international sites 1124-1132 .
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