By herpesviruses especially.

Qian Zhang, M .D., Jeremiah C. Davis, M.P.H., Ian T. Lamborn, B.S., Alexandra F. Freeman, M.D., Huie Jing, Ph.D., Amanda J. Favreau, B.S., Helen F. Matthews, B.S.N., Joie Davis, M.S.N., Maria L. Turner, M.D., Gulbu Uzel, M.D., Steven M. Holland, M.D., and Helen C. Su, M.D., Ph.D.: Mixed Immunodeficiency Connected with DOCK8 Mutations Inherited susceptibility to viral infections, by herpesviruses especially, occurs in patients who’ve developmental defects of T cells, such as for example severe combined immunodeficiency; disorders regarding cell eliminating by cytotoxic lymphocytes, such as hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease; and impaired type We production interferon.1,2 Several other circumstances confer susceptibility to human being papillomavirus attacks or molluscum contagiosum.3-6 The hallmarks of severe combined immunodeficiency are impaired T-cell function and a severe scarcity of T cells.