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‘In theory, a medication that restores p53 function ought to be effective against many different kinds of cancer, so long as the individual tumour includes defective p53,’ says study group member Professor Klas Wiman. ‘We should keep in mind, nevertheless, that tumours have become complex.’.. APR-246 may restore function of defective p53 and activate apoptosis in cancer cells The p53 gene plays an integral role in the prevention of cancer, by blocking cell growth and triggering programmed cell apoptosis or death. If, however, p53 has mutated and be defective, the cancers cells can acquire the ability to evade apoptosis and become more resistant to therapy.