Afatinib active against NSCLC nervous system metastases By Laura Cowen.

Afatinib active against NSCLC nervous system metastases By Laura Cowen, medwireNews Reporter Greatly pretreated sufferers with epidermal growth element receptor -mutated non-small-cell lung malignancy and central anxious system metastases may benefit from treatment with afatinib, state German researchers. The team, led by Petra Hoffknecht, from Mathias Spital Rheine, explains that although EGFR-tyrosine kinase inhibitors such as afatinib are now suggested as a first-line treatment for individuals with EGFR mutation-positive NSCLC, data on the efficacy in patients with CNS metastases remain limited Get more information . To handle this, the researchers studied 541 patients with NSCLC who received afatinib within a compassionate use program, initiated to provide usage of the drug for sufferers who experienced disease progression during treatment with erlotinib or gefitinib.

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